Phosphogluconolactonase
WebApr 27, 2009 · The results of this study identified the gene for 6-phosphogluconolactonase in L. monocytogenes and showed that deletion of this gene enhanced activation of a host cytosolic surveillance system. This is the first report that provides a link between the bacterial PPP and activation of a host innate immune response. WebA newly observed phenotype of pgl strains is a lowered frequency of appearance of Bgl+ mutants that can utilize the beta-glucoside salicin. This is likely due to poor growth of Bgl+ pgl strains on salicin due to the accumulation of 6-phosphogluconolactone. MeSH terms Carboxylic Ester Hydrolases / chemistry Carboxylic Ester Hydrolases / genetics*
Phosphogluconolactonase
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WebJan 25, 2024 · In Plasmodium, a bifunctional enzyme named glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase (GluPho) catalyzes the first two steps of the PPP. PfGluPho has been shown to be essential for the growth of blood stage Plasmodium falciparum parasites. WebAug 2, 2006 · In this context, the crystal structure of 6-phosphogluconolactonase (6PGL) from T. brucei, the second enzyme from PPP, was determined at 2.1 Angstroms resolution. Comparison of its sequence and structure to other related proteins in the 6PGL family with a known structure (Thermotoga maritima Tm6GPL 1PBT and Vibrio cholerae Vc6PGL …
WebMar 21, 2024 · The enzyme 6-phosphogluconolactonase catalyses the second step of this pathway, converting 6-phosphogluconolactone to 6-phosphogluconic acid. This enzyme has been known to have a significant involvement in growth, pathogenesis and sensitivity to oxidative stress in bacterial and protozoal pathogens. WebMar 21, 2024 · The hexose monophosphate shunt is a crucial pathway in a variety of microorganisms owing to its vital metabolic products and intermediates such as NADPH, …
WebDec 19, 2024 · 6-phosphogluconolactone Gluconates Reactive Oxygen Species Ribulosephosphates ribulose 5-phosphate Glucosephosphate Dehydrogenase Superoxide … Web6-phosphogluconolactonase EC number EC:3.1.1.31 ( UniProtKB ENZYME Rhea) Short names 6-P-gluconolactonase; Pgl Gene names Name pgl Synonyms ybhE Ordered locus …
WebSynonym (s): Anti-6PGL)] antibody produced in rabbit, Anti-GDH/6PGL endoplasmic bifunctional protein precursor [Includes: Glucose 1-dehydrogenase antibody produced in rabbit, Anti-Hexose-6-phosphate dehydrogenase); 6-phosphogluconolactonase antibody produced in rabbit. Compare. Product No. Clonality. Application. Species Reactivity.
6-Phosphogluconolactonase (EC 3.1.1.31, 6PGL, PGLS, systematic name 6-phospho-D-glucono-1,5-lactone lactonohydrolase) is a cytosolic enzyme found in all organisms that catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconic acid in the oxidative phase of the pentose … See more 6PGL hydrolysis of 6-phosphogluconolactone to 6-phosphogluconic acid has been proposed to proceed via proton transfer to the O5 ring oxygen atom, similar to xylose isomerase See more 6PGL in Homo sapiens exists as a monomer at cytosolic physiological conditions, and is composed of 258 amino acid residues with a total molecular mass of ~30 kDa. The tertiary structure of the enzyme utilizes an α/β hydrolase fold, with both parallel and … See more • 6-phosphogluconolactonase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Collard F, Collet JF, Gerin I, Veiga-da-Cunha M, Van Schaftingen E … See more 6-phosphogluconolactonase catalyzes the conversion of 6-phosphogluconolactone to 6-phosphogluconic acid, both intermediates in the oxidative phase of the pentose phosphate pathway See more Malarial parasites Plasmodium berghei and Plasmodium falciparum have been shown to express a bi-functional enzyme that exhibits both See more bingo in missouriWebOct 26, 2024 · Here, by analyzing the liver cell single-cell sequencing data from HCC patients and healthy individuals, we found that 6-phosphogluconolactonase (PGLS), a cytosolic … d365 pricing for educationWebDec 19, 2024 · The second enzyme in the oxiPPP, 6-phosphogluconolactonase (PGLS), converts 6PGL to 6-phosphogluconate (6PG). The third enzyme in the pathway, 6PGD, … bingo in my area saturday afternoonWebPGLS ELISA Kits (6-phosphogluconolactonase (PGLS)) Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. recommended PGLS ELISA Kit (ABIN1119585) PGLS Reactivity: Rat Colorimetric Show Details recommended PGLS ELISA Kit (ABIN1119584) PGLS Reactivity: Mouse Colorimetric Show Details recommended … d365 power platform admin centerWebFigure 1. Structure of 6-phosphogluconolactonase. Mechanism It has been proposed that the hydrolysis of 6-phosphogluconolactone from 6PGL to 6-phosphogluconate is carried … bingo in new jerseyWeb6-Phosphogluconolactonase (6PGL, PGLS) is a cytosolic enzyme found in all organisms that catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconic acid in the … bingo in newcastleWeb6-Phosphogluconolactonase (6PGL, PGLS) is a cytosolic enzyme found in all organisms that catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconic acid in the oxidative phase of the pentose phosphate pathway. [2] bingo in new castle pa