Cftr interactome
WebJan 17, 2024 · Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride channel found in secretory epithelia with a plethora of known interacting proteins. Mutations in the CFTR gene cause cystic fibrosis (CF), a disease that leads to progressive respiratory illness and other complications of pheno … WebJun 1, 2016 · Through the development of novel methods for in vivo structural characterization of proteins by mass spectrometry and investigation of post-translational modifications of CFTR, we aim to understand the interrelationship between protein conformation, post-translational modification and protein-protein interaction in Cystic …
Cftr interactome
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WebNational Center for Biotechnology Information Web∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Deletion of phenylalanine 508 of the cystic fibrosis transmembrane conductance regulator (∆F508 CFTR) is the major cause of cystic fibrosis, one of the most common inherited childhood diseases. The mutated CFTR anion channel is not fully glycosylated and shows ...
WebNov 17, 2016 · CFTR can be considered a touchstone for methods that aim at determining membrane protein interactomes, because of its low abundance (≤100 molecules per cell … WebPublication ∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Pankow S, Bamberger C, Calzolari D, Martinez-Bartolome S, Lavallee-Adam M, Balch WE, Yates JR. Deletion of phenylalanine 508 of the cystic fibrosis transmembrane conductance regulator (∆F508 CFTR) is the major cause of cystic fibrosis, one of the most common …
WebApr 27, 2024 · Cystic fibrosis is an autosomal recessive disorder due to mutations in CFTR gene leading to abnormality of chloride channels in mucus and sweat producing cells. Respiratory system and GIT are primarily involved but eventually multiple organs are affected leading to life threatening complications. WebFeb 23, 2024 · Here, we report the analysis of CFTR and ∆F508-CFTR interactomes using BioID (proximity-dependent biotin identification), a technique that can also detect …
WebApr 4, 2024 · CFTR interacts with many proteins that regulate its biogenesis, folding, trafficking, post-translational modifications, and function. In recent years, there has been …
WebTo the Editors: The epithelial sodium channel (ENaC) is part of the complex protein cystic fibrosis transmembrane conductance regulator (CFTR)-interactome that plays a key role in the composition of the airway surface liquid and the mucociliary clearance in the airways. We have recently screened ENaC beta and gamma genes in 55 patients with diffuse … relationship mesh githubWebAug 17, 2024 · Moreover, SFPQ is part of the CFTR-interactome, acting in concert with poly-pyrimidine tract-binding protein (PTBP1) 74. Thus, multiple processes, in which SFPQ plays a central role, are operating ... productivity pdfWebNov 30, 2015 · Here we report the first comprehensive analysis of the CFTR and ∆F508 CFTR interactome and its dynamics during temperature shift and inhibition of histone … Extended Data Figure 4 Interaction Profiles of Proteins Selected for The RNAi … Extended Data Figure 8 Halide Assay Results for CFTR Chloride Channel … Extended Data Figure 3 Overview of Drug Treatment, siRNA-mediated Knockdown … Extended Data Figure 2 CFTR Interactome and Validation of Novel Interactors - … Extended Data Figure 9 Percentage of CFTR Interactors Associated With … Extended Data Figure 7 ∆F508 CFTR Detection in Primary Bronchial Epithelial … productivity pearson log inWebcystic fibrosis CFTR interactome protein-protein interactions proteomics interactome mapping; 38. A Novel Pentapeptide Targeting Integrin β3-Subunit Inhibits Platelet Aggregation and Its Application in Rat for Thrombosis Prevention. relationship mentoring uniWebFeb 22, 2024 · CFTR is activated by cAMP-dependent phosphorylation at the regulatory (R) domain. Therefore, the CFTR-AKAP (ezrin) ... According to proteomics studies of the mRNA complex (mRNA interactome), ezrin was listed as one of the RNA binding proteins (RBPs) [93,94]. Therefore, ezrin seems to be a component of a messenger ribonucleoprotein. … productivity penWebWS11.5 Evaluation of combinations of the CFTR potentiator dirocaftor, corrector posenacaftor and amplifier nesolicaftor in cystic fibrosis subjects with two copies of the … productivity pay gapWebFeb 15, 2024 · The team tested for interactions between CFTR and nearly 10,000 other proteins, and identified 447 that interacted with wild-type (healthy) CFTR and/or with … productivity pay